{"id":280,"date":"2015-03-17T23:42:19","date_gmt":"2015-03-17T23:42:19","guid":{"rendered":"http:\/\/centredebienetreholistique.com\/?p=280"},"modified":"2019-11-27T03:30:24","modified_gmt":"2019-11-27T03:30:24","slug":"lananas-est-superieur-a-la-chimie-5-fu-5-fluouracil","status":"publish","type":"post","link":"https:\/\/centredebienetreholistique.com\/?p=280","title":{"rendered":"L’ananas est sup\u00e9rieur \u00e0 la chimio 5-FU (5-fluouracil)"},"content":{"rendered":"
Une \u00e9quipe de chercheurs et scientiques on publi\u00e9 dans la revue Planta Medica les r\u00e9sultats d’extraits d’annas comme \u00e9tant sup\u00e9rieurs \u00e0 l’agent cytotoxique 5-fluorauracil in vivo (i.e., exp\u00e9rimentation animale, voir l’\u00e9tude ci-dessous). La chimio 5-FU est un poison non seulement pour les cellules canc\u00e9reuses, mais aussi pour toutes les autres cellules humaines qui se divisent rapidement (par ex, les cellules immunitaires, les cellules des cheveux, des intestins etc), vu que le m\u00e9canisme d’action de cette drogue cible et inhibe la synth\u00e8se RNA et ses enzymes de reproduction. A contrario, \u00a0les mol\u00e9cules naturelles comme les enzymes bromelaines des ananas sont g\u00e9n\u00e9ralement dot\u00e9es d’une cytotoxicit\u00e9 s\u00e9lective,<\/strong> \u00a0poussant les cellules handicap\u00e9es comme les cellules canc\u00e9reuses \u00e0 s’\u00e9liminer d’elle memes (via le m\u00e9canisme de l’apoptose), tout en gardant l’ensemble des autres cellules intact. \u00a0Pire, la chimio cytotoxique a tendance \u00e0 renforcer la chimio-r\u00e9sistance ainsi que les cellules canc\u00e9reuses souches, lesquelles deviennent encore plus agressives, tout en profitant pour se disperser au travers du corps, nonobstant une certain r\u00e9duction tumorale de l’excroissance primaire.<\/h5>\n
\"pineappleCRoK\"<\/a>Attribution photo :\u00a0 Creative Commons \u00a0et Wikipedia<\/h6>\n

 <\/p>\n

Planta Med. 2007 Oct;73(13):1377-83. Epub 2007 Sep 24.<\/p>\n

In vivo antitumoral activity of stem pineapple (Ananas comosus) bromelain.
\nB\u00e1ez R1, Lopes MT, Salas CE, Hern\u00e1ndez M.<\/p>\n

Abstract<\/p>\n

Stem bromelain (EC 3.4.22.32) is a major cysteine proteinase, isolated from pineapple ( Ananas comosus) stem. Its main medicinal use is recognized as digestive, in vaccine formulation, antitumoral and skin debrider for the treatment of burns. To verify the identity of the principle in stem fractions responsible for the antitumoral effect, we isolated bromelain to probe its pharmacological effects. The isolated bromelain was obtained from stems of adult pineapple plants by buffered aqueous extraction and cationic chromatography. The homogeneity of bromelain was confirmed by reverse phase HPLC, SDS-PAGE and N-terminal sequencing. The in vivo antitumoral\/antileukemic activity was evaluated using the following panel of tumor lines: P-388 leukemia, sarcoma (S-37), Ehrlich ascitic tumor (EAT), Lewis lung carcinoma (LLC), MB-F10 melanoma and ADC-755 mammary adenocarcinoma. Intraperitoneal administration of bromelain (1, 12.5, 25 mg\/kg), began 24 h after tumor cell inoculation in experiments in which 5-fluorouracil (5-FU, 20 mg\/kg) was used as positive control. The antitumoral activity was assessed by the survival increase (% survival index) following various treatments. With the exception of MB-F10 melanoma, all other tumor-bearing animals had a significantly increased survival index after bromelain treatment. The largest increase ( approximately 318 %) was attained in mice bearing EAT ascites and receiving 12.5 mg\/kg of bromelain. This antitumoral effect was superior to that of 5-FU, whose survival index was approximately 263 %, relative to the untreated control<\/strong>. Bromelain significantly reduced the number of lung metastasis induced by LLC transplantation, as observed with 5-FU. The antitumoral activity of bromelain against S-37 and EAT, which are tumor models sensitive to immune system mediators, and the unchanged tumor progression in the metastatic model suggests that the antimetastatic action results from a mechanism independent of the primary antitumoral effect.<\/p>\n

\"LOGOcentrePy\"<\/a><\/p>\n

Copyright: \u00a0Centre Pyr\u00e9n\u00e9en de Bien-Etre Holistique<\/p>\n

Toutes les informations contenues dans les blogs, articles et \u00e9tudes de ce Blog sont pr\u00e9sent\u00e9es \u00e0 titre \u00e9ducatif et ne peuvent pas \u00eatre interpr\u00e9t\u00e9es comme avis m\u00e9dical<\/p>\n","protected":false},"excerpt":{"rendered":"

Une \u00e9quipe de chercheurs et scientiques on publi\u00e9 dans la revue Planta Medica les r\u00e9sultats d’extraits d’annas comme \u00e9tant sup\u00e9rieurs \u00e0 l’agent cytotoxique 5-fluorauracil in vivo (i.e., exp\u00e9rimentation animale, voir l’\u00e9tude ci-dessous). La chimio 5-FU est un poison non seulement …<\/p>\n

L’ananas est sup\u00e9rieur \u00e0 la chimio 5-FU (5-fluouracil)<\/span> Read More »<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/centredebienetreholistique.com\/index.php?rest_route=\/wp\/v2\/posts\/280"}],"collection":[{"href":"https:\/\/centredebienetreholistique.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/centredebienetreholistique.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/centredebienetreholistique.com\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/centredebienetreholistique.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=280"}],"version-history":[{"count":8,"href":"https:\/\/centredebienetreholistique.com\/index.php?rest_route=\/wp\/v2\/posts\/280\/revisions"}],"predecessor-version":[{"id":2895,"href":"https:\/\/centredebienetreholistique.com\/index.php?rest_route=\/wp\/v2\/posts\/280\/revisions\/2895"}],"wp:attachment":[{"href":"https:\/\/centredebienetreholistique.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=280"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/centredebienetreholistique.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=280"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/centredebienetreholistique.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=280"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}